The short answer
Yes. Rebuilt or re-downloaded automatically when needed.
What is it?
A database that indexes the conformed audio and peak files kept in Media Cache Files, so Premiere Pro, After Effects and Media Encoder know which cached file belongs to which piece of media. It is usually much smaller than the files it tracks.
What happens if you delete it?
Rebuilt automatically when an Adobe app next imports or opens media. Clear it together with Media Cache Files so the two stay consistent.
How to remove it properly
Use the Media Cache settings in Premiere Pro, or Clean Database & Cache in After Effects › Settings › Media & Disk Cache. Or quit every Adobe app and move ~/Library/Application Support/Adobe/Common/Media Cache to the Trash.
Quit the app that uses it, then move it to the Trash. Empty the Trash when you’re sure.
How MoreRoom helps
MoreRoom recognises this item, shows its real size and when it was last used, and labels it “Safe to remove”. In the free version you can move it to the Trash in one click, with Undo; Pro collects every safe item at once.
Frequently asked questions
Is it safe to delete the Adobe Media Cache database?
Yes. Rebuilt or re-downloaded automatically when needed. Rebuilt automatically when an Adobe app next imports or opens media. Clear it together with Media Cache Files so the two stay consistent.
Will Adobe media cache database come back after I delete it?
Yes. Rebuilt automatically when an Adobe app next imports or opens media. Clear it together with Media Cache Files so the two stay consistent.
How do I remove Adobe media cache database properly?
Use the Media Cache settings in Premiere Pro, or Clean Database & Cache in After Effects › Settings › Media & Disk Cache. Or quit every Adobe app and move ~/Library/Application Support/Adobe/Common/Media Cache to the Trash.