The short answer
Yes. Rebuilt or re-downloaded automatically when needed.
What is it?
Update packages downloaded by GoogleUpdater, the background service that keeps Chrome and other Google apps up to date. Packages for updates that are already installed are not needed again.
What happens if you delete it?
The updater downloads new packages when the next update arrives. Installed apps are unaffected.
How to remove it properly
Move ~/Library/Application Support/Google/GoogleUpdater/crx_cache to the Trash in Finder (Go › Go to Folder…).
Quit the app that uses it, then move it to the Trash. Empty the Trash when you’re sure.
Before you delete it
Remove only the cache, not GoogleUpdater itself, unless you are uninstalling Google software: without it Chrome stops updating.
How MoreRoom helps
MoreRoom recognises this item, shows its real size and when it was last used, and labels it “Safe to remove”. In the free version you can move it to the Trash in one click, with Undo; Pro collects every safe item at once.
Frequently asked questions
Is it safe to delete GoogleUpdater’s crx_cache folder?
Yes. Rebuilt or re-downloaded automatically when needed. The updater downloads new packages when the next update arrives. Installed apps are unaffected.
Will Google updater downloads come back after I delete it?
Yes. The updater downloads new packages when the next update arrives. Installed apps are unaffected.
How do I remove Google updater downloads properly?
Move ~/Library/Application Support/Google/GoogleUpdater/crx_cache to the Trash in Finder (Go › Go to Folder…).